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doi: 10.1038/s41572-025-00630-5

16,27 Steroidal MRAs (e.g., spironolactone and eplerenone) carry a Class 2a recommendation in both the AHA and JCS/JHFS guidelines and may reduce HF hospitalizations in selected subsets of patients with HFpEF, whereas the European Society of Cardiology (ESC) guidelines do not provide specific recommendations for their use in this population

Several factors may contribute to anxiety-like symptoms in patients taking tirzepatide

However, only a small amount of metformin was transported through the outer basement membrane of the small intestinal epithelial cells into the bloodstream, resulting in metformin accumulation in these cells ( 3.2 Lactic acidosis During metformin treatment, plasma lactate concentration increases with enhanced glucose uptake in the intestine, resulting in side effects in some patients with one or more risk factors for lactic acidosis ( in vitro cell culture experiments (Yang et al., 2021), potentially leading to a rise in anaerobic glucose metabolism

Some studies indicate that the GIP component may make patients less nauseous than those taking a GLP-1 agonist alone