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Despite significant improvements in glycemic control with both agents, particularly a 1.3% HbA1c reduction with liraglutide, and modest weight loss, 16S rRNA sequencing of fecal samples showed no significant changes in either alpha or beta diversity of the gut microbiota across groups

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doi: 10.1152/ajpregu.00679.2005

The number of patients without diabetes but with overweight or obesity starting GLP-1RA treatment rose from approximately 21,000 in 2019 to over 174,000 in 2023, marking an increase of more than 700%

Consequent endothelium damage results in increased permeability of the endothelium due to disruption of cellcell junction (18)