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This could relate to different pharmacokinetic profiles, lower peak drug levels, or differences in how the oral versus injectable forms interact with the nervous system

The ISSNs 2023 position stand on EAA supplementation (Ferrando et al., 2023) makes the case directly: EAA requirements increase during caloric deficits , free-form EAAs stimulate MPS more effectively than equivalent intact protein, and doses as low as 1.53 g can trigger a synthesis response at rest

Sleep deprivation increases cravings and insulin resistance