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In SURMOUNT-1 (NEJM 2022, 2,539 adults with obesity), the 15 mg arm averaged 22.5% body weight loss at 72 weeks, the 10 mg arm 21.4%, and the 5 mg arm 16.0%

Individual results varied widely - some participants lost significantly more, some lost less, and some did not lose substantial weight even on the highest doses

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These hormones are GLP-1, Glucagon-Like Peptide-1, which binds to receptors in the brain and the pancreas to create the sensation of feeling full by slowing the digestive process, and GIP, Gastric Inhibitory Peptide, which works very similarly in the way it slows digestion but it binds to other receptors in the brain but help the body create insulin resulting in a decrease in food cravings and appetite