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Researchers analyzed Fitbit data found that daily step counts and exercise levels dropped after people started these medications, despite successful weight loss

Serious but Rare Risks Serious risks, while uncommon, may include thyroid tumors observed in animal studies, acute pancreatitis, gallbladder disease related to rapid weight loss, kidney function impairment associated with dehydration, hypoglycemia when combined with certain diabetes medications, and severe allergic reactions

These may include depression, anxiety, and a reduced ability to experience pleasure

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Gastrointestinal side effects like nausea, constipation, or reduced appetite from semaglutide can temporarily impact eating patterns, though these typically diminish within 1 to 2 weeks as your body adjusts