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Semaglutide activates a single receptor (GLP-1), while tirzepatide is a dual agonist that adds the GIP receptor on top of GLP-1

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Triple-Receptor Mechanism Explained Understanding how Retatrutide functions requires looking at each receptor it activates and what that activation does at a cellular signalling level: GLP-1 Receptor Activation GLP-1 receptors are incretin receptors that play a central role in regulating postprandial insulin secretion and gastric motility

These GLP-1 agonist medications may help regulate appetite, support satiety, and play a role in broader provider-directed metabolic health strategies

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