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The drug may cause changes in metabolic processes and hormonal levels that can activate coagulation pathways, increasing the tendency for blood to clot

Proc Natl Acad Sci 114:16431648 Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Gktuna SI, Ziegler PK et al (2013) Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

MRI), comparison of the effect of GLP-1RA treatment according to the presence or absence of T2DM is insufficient

Gastrointestinal side effects are the most common and include: Nausea (reported in 12% to 29% of patients, depending on dose) Diarrhea (occurring in 13% to 23% of patients) Vomiting (affecting 4% to 9% of patients) Constipation (reported in 6% to 11% of patients) Abdominal pain and dyspepsia (affecting 6% to 9% of patients) Decreased appetite (common and often contributes to weight loss) These gastrointestinal symptoms typically occur during dose escalation and often improve with continued use