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Because of the rapid degradation of GLP-1, therapeutic use of GLP-1 to enhance insulin secretion makes use of long acting, degradation resistant analogs of GLP-1 or DPP-4 inhibitors
Cardiovascular protective effects have been observed with both drug classes, reducing major adverse cardiovascular events in patients with T2DM and obesity and demonstrating symptomatic benefits in HFpEF
The acylation does not appear to influence the potency of action at the GIPR, enabling tirzepatide to act as a full agonist at the human GIPR
Angioedema is similar to hives, but swelling occurs under the skin rather than on the surface
Childhood and adolescent obesity in the United States: A public health concern
