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Description
Enzyme selectivity for cleavage immediately C-terminal to proline or alanine residues at position 2 substrate peptides is dictated by the shape and size of the S1 pocket, which is lined by Val656, Tyr631, Tyr662, Trp659, Tyr666, and Val711 (Figure 6)

Theyre often included in proprietary blends at doses below those used in research studies showing even modest effects

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It's the legal basis for the prescription

Time runs along the horizontal axis (typically in weeks)