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Description
One phase IIb clinical trial administered setmelanotide to obese participants with heterozygous MC4R deficiency and obese controls over 28 days, observing a placebo-adjusted weight loss of 2.6 kg and 4.0 kg respectively [98]

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doi:10.1210/jc.2010-2081

Although not a pure GLP-1 drug (its often called a twincretin because it harnesses two incretins), it represents the next wave of therapy building on GLP-1s foundation
