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It works best as part of a long-term plan

GLP-1 mechanism of action When the natural hormone or GLP-1 drugs bind to the GLP-1 receptor, they trigger an intracellular signaling cascade

Wegovy (semaglutide) EPAR (European Commission decision and product overview)

But they can strengthen a case for medical necessity in borderline situations, support off-label prescribing decisions, and help providers make more nuanced clinical judgments