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Moreover, mice with targeted inactivation of GLP-1R in autonomic neurons targeted by Phox2b, including the nodose ganglion, exhibit impaired glucose homeostasis, accelerated gastric emptying, and increased levels of GLP-1, glucagon, and insulin, supporting the importance of vagal afferent GLP-1Rs for metabolic homeostasis [520]

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Study participants treated with 300 mg once daily exhibited weight loss of 4.4 kg at 54 weeks, greater than that observed with liraglutide ( yet slightly less than the maximal weight loss achieved with semaglutide in similar patient populations [60]

Liraglutide (Saxenda, Victoza) Liraglutide is a daily GLP-1 medication with a 13-hour half-life