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Additionally, GLP-1 suppresses glucagon, another hormone responsible for raising blood sugar, further stabilizing glucose levels

Skye is conducting a Phase 2 clinical trial ( ClinicalTrials.gov: NCT06577090 ) in obesity for nimacimab, a negative allosteric modulating antibody that peripherally inhibits CB1

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In brain centers, LepRs were found in GLP-1Rexpressing neurons in the nucleus of the solitary tract and leptin was found to stimulate these neurons (113, 114)