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This distinguishes pan-ERR activation from anorexigenic or stimulant mechanisms and emphasizes direct metabolic reprograming

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Two days after plating, various concentrations of glucose, DCA, triplete, and 007-AM in modified Ringer buffer (RB: 140 mM NaCl, 3.5 mM KCl, 0.5 mM NaH 2 PO 4 , 1.5 mM CaCl 2 , 10-mM HEPES, and 2-mM NaHCO 3 ) containing DPP-4 inhibitor (25 M) and 0.5% (v/v) BSA were administered to the cells, which were then incubated for 2 h

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February 2026 marked a meaningful expansion in the oral GLP-1 landscape, with new data adding to the momentum that began with the FDA approval of oral Wegovy (semaglutide 25 mg tablets) in late 2025