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Nonetheless, the ability of L-cells to secrete GLP-1 in direct response to luminal nutrients certainly plays an additional role, and may be the main mechanism of GLP-1 secretion

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The kidneys are also involved with sympathetic nervous system (SNS) activation and tone, inflammation, and immune regulation [83]

Preclinical and clinical studies have shown that GLP-1s reduce alcohol intake, blunt the pleasurable effects of opioids and stimulants, and might reduce cravings across multiple substance classes

Glycemic control with empagliflozin, a novel selective SGLT2 inhibitor, ameliorates cardiovascular injury and cognitive dysfunction in obese and type 2 diabetic mice