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Due to this, Mounjaro should be discontinued at least 2 months before a planned pregnancy

Ethical concerns arise from the lack of long-term safety data, highlighting the need for further research as the side effect profile continues to evolve with broader use

Discussion The population pharmacokinetic model reported here successfully describes the pharmacokinetics of semaglutide, reproducing the values for CL/F and V/F of approximately 0.05 l/h and 12.5 l, respectively, obtained from clinical pharmacology trials with richly sampled PK profiles in subjects with T2DM (Novo Nordisk, data on file)

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The key to long-term success