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Month 2: Side effects usually ease, appetite reduction stabilizes, and headaches or lingering GI symptoms may appear occasionally

Consequently, the 2024 American Gastroenterology Association (AGA) Rapid Clinical Practice Update recommends that management should depend on upper gastrointestinal symptoms

However, its effectiveness and safety in comparison to semaglutide, another type 2 diabetes medication, have not been studied
DPP-4 inhibitors: Oral medications that help increase insulin production and decrease glucose production in the liver

There is limited evidence that patients who fail to respond to tirzepatide will necessarily respond better to other incretin-based therapies, but individual variation may result in differential responses
