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Her advice to colleagues who are treating people with obesity and low testosterone is not to prescribe "testosterone immediately, look at the broader picture." This article is reproduced with permission and was first published on June 15, 2026 .

Set point resistance : Your body defends against further weight loss through hormonal shifts, including changes in leptin, ghrelin, and insulin sensitivity, that increase hunger and slow metabolism

The now-elevated calcium levels promote exocytosis of GLP-1containing vesicles, releasing GLP-1 into the circulation