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doi:10.1016/S0140-6736(17)30933-9 66

Disturbance of insulin signaling in diabetic patients might lead to the abnormal expression of Syn, damage to mitochondrial function, increase in mitochondrial oxidative stress, and down-regulation of the PI3K/AKT pathway, which in turn could promote the occurrence and development of PD (62)

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Insulin Dose Reduction at GLP-1 RA Initiation In the SUSTAIN-5 trial (N=397), patients on semaglutide 1 mg plus basal insulin experienced a symptomatic hypoglycemia rate of 11.3%, versus 1.1% in the semaglutide-plus-metformin-only arm [6]

Fat-free mass refers to tissue in the body that isn't fat, such as muscle, bone, and skin