triple acting glp 1 Discovery of a potent and long-acting Xenopus GLP-1-based GLP-1/glucagon/Y2 receptor agonist Dual and Triple Gut Peptide

But just to kind of keep us on the, topic of coverage, Im gonna, Suzanne, ask you to maybe, talk through, the next couple slides a little bit

both animal and Caco-2 cell models show that BBR regulates gut microbiota by tryptophan metabolism and activation of the tryptophan receptor (AhR) pathway to improve the damaged intestinal barrier ( Lactococcus is upregulated compared to the model group, but the expression of conditionally pathogenic bacteria such asmouse intestinal Bacteroides , segmented filamentous bacteria, and Enterobacteriaceae decreases

Metformin also works well as a foundation medication when combined with GLP-1 therapy

FDA Regulatory Notice: As of February 2026, the FDA has resolved the semaglutide drug shortage and has stated its intent to prioritize enforcement against certain mass-marketed non-FDA-approved GLP-1 products

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