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A 2025 body-composition substudy added detail on fat-mass versus lean-mass changes within the T2D Phase 2 cohort fat mass accounted for the majority of total weight reduction (PMID 40609566)

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A microdose in community usage means either splitting the standard weekly dose into 2 to 3 injections per week, or starting below 2mg per week as an off-label sensitivity protocol

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As a peptide-based injectable, reconstituted retatrutide is highly sensitive to temperature, light, and contamination