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GLP-1 receptor agonists are now widely prescribed for individuals with type 2 diabetes and weight loss, with a 700% increase in usage reported in the United States between 2019 and 2023. These medications alter glucose metabolism, gastric motility, and sympathetic tone, which may lead to unique uptake patterns on PET-CT

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Clinical relevance and future studies The relationship between diabetes, obesity, and bone health is of significant clinical importance

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However, Ozempic has shown superior weight loss outcomes in patients with PCOS roughly 12-15% body weight reduction compared to metformins 5-8% along with better hormonal regulation