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Abstract GLP-1 was described as an incretin over 30 years ago

Respondents were clear about who they think these medications are really for

Different chemical scaffolds can generate different reactive metabolites, and the safety of one small-molecule GLP-1 agonist does not automatically predict the safety of another

Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination

Early signals of complexity, pleiotropy, or tolerability frequently discouraged further development, despite the possibility that these features could be harnessed through modern pharmacologic strategies