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The mechanism acts on metabolic pathways and regulates the gene expression by binding the peroxisome proliferator-activated-receptor gamma (PPAR-)

Upper back or shoulder area : These sites may be appropriate for patches requiring less frequent patient access, though they can be difficult for self-application

Dyachok et al., 2006)

If the response to treatment is satisfactory, a patients prescription plan may allow for subsequent prescriptions to be filled by mail-order pharmacies for 3-month cycles, which will provide lower out-of-pocket costs for patients and may honor the copayment cards