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doi: 10.1016/j.diabres.2019.107843 4 StrattonIMAdlerAINeilHAMatthewsDRManleySECullCAet al

Comparing Semaglutide to Other GLP-1 Weight Loss Medications Semaglutide and tirzepatide (a GLP-1/GIP dual receptor agonist) both produce significant weight loss, but tirzepatide generally delivers 3-5% greater total body weight reduction in head-to-head trials

Clinical trials show that even modest early weight loss can predict longer-term success and metabolic improvements

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Thus, in patients with advanced disease, it should be viewed primarily as a therapy that modifies metabolic disease