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This renal protection adds another dimension to the therapeutic value of semaglutide for weight loss in non-diabetics who may have early kidney concerns

An early RCT in 44 patients with obesity and subclinical binge eating showed that liraglutide was better than diet and exercise alone in reducing binge-eating scores at 12 weeks 220 , but a later investigation of 27 adults with BED comparing liraglutide against placebo did not find any differences in the number of binging episodes over 17 weeks 218

Trials of tirzepatide in obesity and type 2 diabetes have shown improvements in blood pressure, cholesterol, and HbA1c (a marker of blood sugar control) alongside weight loss, though the SURMOUNT-MMO data will be the clearest evidence on cardiovascular outcomes

L., Madsen, K., Pedersen, F