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In addition, some studies show that GLP-1s may impact muscle protein synthesis

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Hypoglycemia Adverse Reactions in Placebo-Controlled Trials in Patients with Type 2 Diabetes Mellitus Severe hypoglycemia adverse reactions are episodes requiring the assistance of another person

Nutritional supplements that include Vitamin D, B complex, and zinc may be supportive when intake is low

Of note, over the last years, an array of unimolecular GLP1-based poly-agonists, with different mechanisms of action, have been developed and experimentally validated for the treatment of metabolic syndrome, holding superior efficacy relative to conventional GLP1-RA 33,34,35