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For example, overweight and obese T2D patients treated with activin type 2 receptor antagonist bimagrumab in a phase 2 trial achieved net weight loss, comprising significant loss of total body fat mass while gaining some lean mass (i.e

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Vice versa, we illustrate how the dysregulated metabolic-inflammatory axes influence the therapeutic outcomes emphasizing how the adipose tissue microenvironment modulates the response to conventional and targeted therapies

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