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Not instant or permanent : Weight loss is gradual, and stopping the medication often leads to weight regain

These include existing irritable bowel syndrome (IBS), baseline constipation history, rapid dose titration, higher final doses, and certain genetic variants affecting GI motility and bile acid metabolism

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Thyroid Hormone Replacement Dosing after Bariatric Surgery in Patients with Primary Hypothyroidism and Severe Obesity: Tehran Obesity Treatment Study
