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[Wadden STEP 3, JAMA 2021] STEP 5 Trial (Nature Medicine 2022) Long-term data: patients maintained an average 15.2% weight loss over 2 years of continuous semaglutide use, with sustained metabolic improvements including reduced HbA1c, blood pressure, and waist circumference
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Systemic corticosteroids (e.g., 0.50.7 mg/kg oral prednisolone) used in the short-term that are rapidly tapered may help reduce inflammation associated with flares (19)
Without substantial lifestyle modification, success rates drop to roughly 5 percent
2018 Mar 1 [cited 2023 Jun 15];19(3):277.e1277.e8
