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Innovent's mazdutide has gone further: China's NMPA approved mazdutidethe world's first dual GCG [glucagon receptor]/GLP-1 receptor agonistfor chronic weight management in June 2025

In terms of the reduction in total testosterone, 9 studies (with 264 and 223 subjects from the experimental and control groups, respectively) were included in the analysis

ARC GABAergic neurons that express thyrotropin-releasing hormone (TRH), approximately 60% of which expressed GLP-1R, were found to have GABAergic afferents directly targeting AgRP neurons

Neeland IJ, Marso SP, Ayers CR, et al