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LVDP recovery is shown in hearts perfused with 6 nM GLP-1(2836), scrambled(2836) control, or buffer-only control, or with 0.3 nM GLP-1 ( n = 413 WT mice/group
GLP-1Rs are distributed widely throughout the body in humans and model organisms, with particular density in the pancreas -cells, gastrointestinal tract, brain, kidneys, heart, and blood vessels of other organs [17, 18]
doi: 10.1073/pnas.0707054104
The beneficial effects of GLP-1 receptor activation on glycemia occur through several mechanisms: GLP-1 stimulates glucose-dependent insulin secretion from pancreatic -cells, suppresses inappropriately elevated glucagon secretion from pancreatic -cells, delays gastric emptying, and induces satiety via a direct action in the central nervous system
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