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Fracture Risk Data from GLP1 Trials Several cardiovascular outcomes trials (CVOTs) have collected fracture data as secondary outcomes: Trials involving semaglutide and dulaglutide generally report fracture rates similar to placebo A few studies suggest a potential increase in non-vertebral fractures, though findings are inconsistent and often not statistically significant One important confounder is weight loss, which itself can lead to bone loss

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PubMed Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance Used for maintenance, discontinuation, and weight-regain discussions after semaglutide response
So, when you lose all this fat-free mass where youve got a lot of muscle in there, is that going to, in the long term, cause serious issues

It carries minimal hypoglycemia risk and benefits cardiovascular outcomes in some populations
