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This article examines the safety considerations, potential risks, and practical guidance for UK patients considering this combination, helping you make informed decisions about pain relief whilst managing your weight

Current treatments, such as pain relievers, antidepressants, and physical therapy, do not work for everyone, and new options are needed

38 Alphaglucosidase inhibitors, such as acarbose (Precose, Bayer), and bile acid sequestrants, such as coleselvam (Welchol, Sankyo Pharma), are used less frequently because of an elevated incidence of GI side effects

Sarcopenia is also age-associated but may be exacerbated by obesity, leading to higher disability, frailty, morbidity and mortality rates [171]

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