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This suggests that while metformin is able to modulate mammalian testis development, some plasticity in the ability for the testis to recover exists during perinatal periods

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The single most conserved residue among class B GPCRs in each transmembrane helix (designated X.50b in the Wootten residue numbering scheme 16 , in which X is the transmembrane helix number) is indicated in bold

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doi: 10.1016/S0140-6736(17)33102-1