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Based on our study, ER36 deletion is sufficient to attenuate the proliferation and invasiveness of ER36 + breast cancer cells regardless of the presence of ER66
Likewise in Alzheimers Disease (NCT03739905) blood-brain barrier opening has been shown to be focally achieved on PET studies but no therapeutic agents were delivered and opening in and of itself in the so-called default mode network areas did not affect cognitive scores or disease biomarkers 58
As shown in Scheme 10
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