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52 Numerous CREB-regulated genes are under the control of GLP-1R agonists in -cells, as demonstrated for CREB-dependent stimulation of insulin gene expression and insulin receptor substrate-2 (IRS-2) gene expression

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These drugs activate receptors found throughout the body, including in the gastrointestinal system, where they slow digestion and send signals to the brain to enhance feelings of fullness, aiding in weight management

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They contain the same active ingredient as the brand medicine, making them affordable and effective options

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Dosing protocols and administration Both Ozempic and retatrutide are once-weekly subcutaneous injections

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