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38,41 Various modifications of the GLP-1-derived peptide, such as glycosylation, 4446 lipidation, 4749 introduction of lysinolanine 50 and lactam bridges, 51 and the incorporation of d-amino acids, 52 have been explored at different positions to enhance its therapeutic properties
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released preliminary topline week 96 results from Phase 2b study HARMONY The study previously met its primary endpoint of 1 stage improvement in fibrosis with no worsening of MASH after 24 weeks of treatment for both the 50mg EFX (41%) and 28mg EFX (39%) dose groups, compared to 20% for the placebo arm

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It has been suggested that these alterations reflect an energy appeal reaction of the organism providing free energy in the circulation, which is needed by inflammatory cells (158)

Shao W, Wang Z, Ip W, et al
