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Thus, following just three weeks of exercise training, sedentary non-obese participants' NAMPT protein levels rose by 127% in an exercise intervention trial

It was designed by Eli Lilly and first described in 2022 in Cell Metabolism
[DOI] [PubMed] [Google Scholar] 726.Thiele T.E., Roitman M.F., Bernstein I.L

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[5] Some patients with obesity may have mild elevations in cortisol or altered cortisol metabolism related to their weight status, and substantial weight loss could potentially normalise these patterns, though evidence for this specific effect is limited