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Obesity is associated with increased sDPP-4 levels, which also leads to adipocyte insulin resistance through mechanisms related to the interactions with caveolin-1 (Cav-1), expressed on the cell surface of adipocytes and adipose tissue macrophages, as well as increased hepatic insulin resistance [50]

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Interestingly, even in obese swine, GLP-1R activation can improve cardiac function and augment cardiac output after MI [75]

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But again, thats hardly guaranteed