glp-1 sparks How the Big Bang of Behavior Change body and life GLP-1 Advanced Metabolic Extra Strength

J Neurol Neurosurg Psychiatry (2020) 91(8):795808

Rapid weight loss can also cause hair thinning, skin dryness and dullness, and brittle nails due to nutrient shifts

Lancet 393(10166):3139

10 , 17 If the dose is fixed at 2.4 mg but the dosing interval is increased to 14 days (q2wk), the model predicts a steadystate body weight reduction of 12%

Abbreviations GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist T2DM: Type-2 diabetes mellitus DPP-4: Dipeptidyl peptidase 4 HbA1c: Hemoglobin A1c NASH: Non-alcoholic steatohepatitis NAFLD: Non-alcoholic fatty liver disease Camp: Cyclic adenosine monophosphate PKA: Protein kinase A EPAC: Exchange protein directly activated by cAMP PI3K: Phosphoinositide 3-kinase PYY: Peptide YY CCK: Cholecystokinin GLUT4: Glucose transporter type 4 mTORC1: Mammalian target of rapamycin complex 1 References Ahrn B (2015) Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes