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With the presentation of results at the European Society of Cardiology Congress 2024 coming less than a month after the announcement of topline results in early August, the newest data released from the trial provides further insight into the role of the non-steroidal, selective mineralocorticoid receptor antagonist in treatment algorithms for heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF)

In a preprint published on bioRxiv on April 5, 2026, researchers Ulya Keskin, Eslem Altin, Melkan Kagan Kara, Burak Tekin, Kerime Nur Cakircoban, Fikriye Yasemin Ozatik, Neziha Senem Ari, Ayse Kocak Sezgin, and Emre Gungor explored the behavioral and molecular brain-related effects of retatrutide, a novel triple hormone agonist