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This differentiation can be achieved through variations in dosage form, strength, or combinations, provided there is a documented medical need for such modifications. This pathway allows compounding pharmacies to serve patients with specific requirements not met by the standard FDA-approved medications

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This combination is often more effective than either approach alone

3,28 One approach is to prevent degradation by DPP-IV through amino acid substitutions, as this enzyme preferentially cleaves N-terminal Xaa-Pro or Xaa-Ala sequences
