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However, these mechanisms remain speculative in human RA and require validation through dedicated clinical trials

[DOI] [PubMed] [Google Scholar] 62.Del Prato S, Kang J, Trautmann ME, Stewart J, Sorli CH, Derwahl M, et al

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For sites and CROs, the gating review introduces an early stopping checkpoint that can preserve safety and budget but may stretch timelines

It promotes a healthier metabolic state, resulting in increased weight loss
