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EX-4 stimulates the expression of anti-inflammatory M2 microglial markers (including IL-10, IL-4, arginase 1, and CD206), but not that of proinflammatory M1 markers, which are linked to neuroprotection and antinociception in neuropathic rats [50]

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So much so that for some of us, a 2.5-mg low dose or microdose of tirzepatide (which costs $299 per month from the LillyDirect pharmacy) may be more effective and cheaper than high doses of alternatives like Ozempic and Wegovy

Given the temporal relationship with the initiation of tirzepatide and the absence of other triggers (e.g., infection, postpartum state, or medication use), a diagnosis of drug-induced painless thyroiditis was made