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Research notes that many people report a preference for oral medication over injections, and injectable drugs can act as a barrier for initiating treatment

Tamara Hannon, a pediatric endocrinologist with Indiana University and lead author of the recent tirzepatide trial for kids, tells Yahoo

Dose Escalation Structure Phase Weekly Dose Weeks 14 1 mg Weeks 58 2 mg Weeks 912 4 mg Maintenance (research range) 68 mg Clinical trials have evaluated doses up to 12 mg once weekly with gradual titration

Given the observed increased risk of colorectal cancer among patients receiving GLP-1 receptor agonists, clinicians should approach long-term prescribing of these agents with careful consideration, particularly in individuals with additional risk factors for colorectal cancer, such as a family history, obesity, inflammatory bowel disease, or long-standing type 2 diabetes

Understanding this mechanism helps explain why certain considerations arise when combining it with other medications