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Failing heart-relevant processes included increased uptake of long-chain fatty acids, impaired ATP production, cytosolic accumulation of deleterious lipid intermediates, impaired mitochondrial function, suppression of nutrient-deprivation signaling, cytosolic accumulation of amino acids driving aberrant mTOR activation, and inflammation-mediated functional iron deficiency with altered metabolism
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Optimising thyroid replacement and evidence-based lifestyle interventions should be explored as first-line approaches before considering GLP-1 medications

Previous studies have shown that GLP-1s can reduce pressure inside the skull, which is a possible cause of migraines, according to multiple health organizations
