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Author contributions CT: Investigation, Visualization, Writing original draft

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People who take CONTRAVE must not use any type of opioid including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE

Retatrutide Heart Rate Increase: Mechanism, Evidence, and Clinical Guidance Retatrutide heart rate increase is an important safety consideration for this investigational triple agonist, which simultaneously targets GLP-1, GIP, and glucagon receptors