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Additionally, the observed weight loss and reduction in systolic blood pressure in the GLP-1RA group may also contribute to the cardiovascular benefits 21,22

Similarly, while niacinamide is generally well-tolerated, individuals with known sensitivities to B-vitamins or nicotinic acid derivatives should exercise caution

These benefits were achieved without serious adverse effects, and GLP-1 RA use was associated with reduced reliance on acetazolamide and avoidance of surgical interventions

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