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In the Phase 3 ATTAIN-1 trial, patients taking the highest dose of Foundayo (36 mg once daily) achieved a mean weight loss of about 11.2% to 12.4% over 72 weeks, depending on whether analyses included all randomized participants or focused on those who remained on treatment

This review identified key mechanisms, including CCK suppression, disruption of FXR and TGR5 signaling, and alterations in bile acid composition, that may contribute to impaired gallbladder motility and gallstone formation

Suspected adverse reactions, including those occurring within clinical trials, should be reported via the MHRA Yellow Card scheme

Drug stability remains a concern, particularly for sensitive neuroprotective agents such as NGF and BDNF, which are vulnerable to temperature fluctuations [105]

Anxiety and mood changes can occur, particularly during rapid weight loss phases